MINS Study: Myocardial injury after noncardiac surgery sub-study of the VAPOR-C Trial
Hypothesis and aims
We hypothesise that the use of intraoperative intravenous lidocaine infusion during major surgery will reduce the incidence of MINS compared to placebo.
1) To compare the incidence of MINS with the use of intraoperative intravenous lidocaine to placebo.
Endpoint definition: MINS will be defined as a Troponin level (Troponin I or Troponin T) greater than the 99th percentile of the upper reference limit, in accordance with the Fourth Universal Definition of Myocardial Infarction .
1) To measure the association between perioperative inflammatory changes, troponin rise, MINS and postoperative outcomes.
Endpoints: length of stay (days); postoperative complications and mortality at 30 days and 1 year. Perioperative inflammatory change will be measured by perioperative change in C-Reactive Protein (CRP), neutrophil-lymphocyte ratio (NLR) and inflammatory cytokines.
Participants recruited to the VAPOR-C Trial will be eligible for inclusion in the MINS Study and approached for recruitment.
Dr Justin Nazareth
Dr Tim Coulson
Dr Julia Dubowitz
Professor Bernhard Riedel
Dr Mark Nolan
Professor Philip Peyton
Professor P J Devereaux
Australian and New Zealand College of Anaesthetists
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