Project Details


TRICS IV: Restrictive versus Liberal Transfusion in Younger Patients Undergoing Cardiac Surgery

An international, multi-centre, randomised controlled trial to assess transfusion thresholds in younger patients undergoing cardiac surgery.

1,440 patients will be enrolled internationally.

Study design: Multi-centre open-label randomised controlled trial (RCT) of a restrictive versus liberal transfusion strategy in higher risk patients ≤65 years of age having cardiac surgery on cardiopulmonary bypass, using a superiority trial design.

Hypothesis: A higher haemoglobin (Hb) concentration for red blood cell (RBC) transfusion (liberal transfusion strategy) will be superior to a restrictive strategy in terms of vital organ function (heart, brain and kidney) and mortality 6 months after cardiac surgery.

Principal Investigator (Canada)
Dr David Mazer, St. Michael’s Hospital (Toronto, ON, Canada)

Principal Investigator (Australia)
Professor David Scott,  Department of Critical Care and St Vincent's Hospital, Melbourne

Trial Manager (Australia)
Bhavita Patel, TRICS IV Trial Coordinator, Department of Critical Care, University of Melbourne


Prof David Scott
Prof Alistair Royse
Dr Raymond Hu
Prof John Fraser
Prof Cyril David Mazer
Dr Nadine Shehata
Prof Paul Bannon
Prof James Isbister


St Vincent's  Hospital, Melbourne
St. Michael’s Hospital (Toronto, ON, Canada)
Australian and New Zealand College of Anaesthetists Clinical Trials Network (ANZCA CTN)


MRFF ICTC Grant $869,565 (2021-2024)

Research Group

Anaesthesia, Perioperative and Pain Medicine

School Research Themes

Integrated Critical Care in Medicine

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Critical Care

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