The STRIDENT Study
-
Project Lead
Professor Michael Kamm
Project Details
Stricture Definition and Treatment (the STRIDENT Study)
Most patients with Crohn’s disease at some stage develop complications of the disease and require an operation. The most common complication is bowel narrowing.
The STRIDENT studies aim to heal the bowel using intense treatment, or stretch narrowing more effectively, to prevent the need for an operation.
The STRIDENT (Stricture Definition and Treatment) studies focus on treating Crohn’s disease complications more effectively. They examine how intense drug treatment can heal the bowel, preventing the need for surgery. They also research more effective ways to safely stretch the bowel, relieving obstruction.
These are the first studies of this type in the world to address this particular Crohn’s disease complication.
Researchers
Professor Michael Kamm – Group Leader
Dr. Amy Hamilton – Clinical Scientist
Dr. Bronte Holt – Gastroenterologist
Ms. Alyson Ross – Research Nurse
Dr. Julien Schulberg – Gastroenterologist and PhD Fellow
Dr. Emily Wright – Gastroenterologist
Collaborators
AbbVie
Professor Mark Morrison – The University of Queensland Diamantina Institute
Dr Greg Moore – Monash University
Funding
NHMRC
AbbVie
The Spotlight Foundation
Research Publications
Efficacy of drug and endoscopic treatment of Crohn's disease strictures: A systematic review.
Schulberg JD, Wright EK, Holt BA, Wilding HE, Hamilton AL, Ross AL, Kamm MA.J Gastroenterol Hepatol. 2021 Feb;36(2):344-361. doi: 10.1111/jgh.15330. Epub 2020 Dec 27.PMID: 33150989
Schulberg JD, Wright EK, Holt BA, Hamilton AL, Sutherland TR, Ross AL, Vogrin S, Miller AM, Connell WC, Lust M, Ding NS, Moore GT, Bell SJ, Shelton E, Christensen B, De Cruz P, Rong YJ, Kamm MA.Lancet Gastroenterol Hepatol. 2022 Apr;7(4):318-331. doi: 10.1016/S2468-1253(21)00393-9. Epub 2021 Dec 8