• Project Lead
    Professor Michael Kamm

Project Details

Stricture Definition and Treatment (the STRIDENT Study)

Most patients with Crohn’s disease at some stage develop complications of the disease and require an operation. The most common complication is bowel narrowing.

The STRIDENT studies aim to heal the bowel using intense treatment, or stretch narrowing more effectively, to prevent the need for an operation.

​The STRIDENT (Stricture Definition and Treatment) studies focus on treating Crohn’s disease complications more effectively. They examine how intense drug treatment can heal the bowel, preventing the need for surgery.  They also research more effective ways to safely stretch the bowel, relieving obstruction.​

​These are the first studies of this type in the world to address this particular Crohn’s disease complication.


Professor Michael Kamm – Group Leader

Dr. Amy Hamilton – Clinical Scientist

Dr. Bronte Holt – Gastroenterologist

Ms. Alyson Ross – Research Nurse

Dr. Julien Schulberg – Gastroenterologist and PhD Fellow

Dr. Emily Wright – Gastroenterologist



Professor Mark Morrison – The University of Queensland Diamantina Institute

Dr Greg Moore – Monash University




The Spotlight Foundation

Research Publications

Efficacy of drug and endoscopic treatment of Crohn's disease strictures: A systematic review.

Schulberg JD, Wright EK, Holt BA, Wilding HE, Hamilton AL, Ross AL, Kamm MA.J Gastroenterol Hepatol. 2021 Feb;36(2):344-361. doi: 10.1111/jgh.15330. Epub 2020 Dec 27.PMID: 33150989

Intensive drug therapy versus standard drug therapy for symptomatic intestinal Crohn's disease strictures (STRIDENT): an open-label, single-centre, randomised controlled trial.

Schulberg JD, Wright EK, Holt BA, Hamilton AL, Sutherland TR, Ross AL, Vogrin S, Miller AM, Connell WC, Lust M, Ding NS, Moore GT, Bell SJ, Shelton E, Christensen B, De Cruz P, Rong YJ, Kamm MA.Lancet Gastroenterol Hepatol. 2022 Apr;7(4):318-331. doi: 10.1016/S2468-1253(21)00393-9. Epub 2021 Dec 8

Research Group

Michael Kamm

School Research Themes

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre



St Vincent's Hospital

MDHS Research library
Explore by researcher, school, project or topic.