Perinatal outcomes of Simplified Screening versus standard 2-hr 75g Oral glucose tolerance for diagnosis of gestational diabetes mellitus (POSSOM): A pilot randomised control trial

  • Shane Hamblin

  • Group Leader
    Shane Hamblin

Project Details

This project aims to assess the feasibility of performing a randomised control trial to assess the use of a simplified screening method in comparison with the standard 2-hour 75g-oral glucose tolerance test for the diagnosis of gestational diabetes mellitus (GDM). Perinatal outcomes will be compared between the two screening arms.  During the COVID-19 pandemic, a simplified screening method was adopted which utilised a fasting plasma glucose level instead of the standard oral glucose tolerance test to screen for GDM.  The fasting plasma glucose result either diagnosed GDM, determined no GDM or, if the result was an intermediate value, it determined the need for further screening with an oral glucose tolerance test.  A retrospective comparative cohort study has been performed comparing the perinatal outcomes of women screened for GDM with the modified simplified screening compared with the outcomes of women screened with conventional screening prior to the COVID-19 pandemic.  Perinatal outcomes were non-inferior for women screened with the simplified screening method compared with conventional screening.  These results from our retrospective study form the basis of further investigating this screening method through a prospective randomised controlled trial.


Dr I-Lynn Lee
Dr Dev Kevat
A/Prof Christopher Yates
Dr Jessica Deitch
Ms Cheryl Steele
Dr Elske Posma
Dr Niranjan Abraham
A/Prof Shane Hamblin
A/Prof Joanne Said
A/Prof Glyn Teale

Research Group

Western Health Endocrinology and Diabetes Research Group

School Research Themes

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre


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