Undescended testis and inguinal hernia result from defects in the same mechanism
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The Surgical Research Group works on a number of surgical problems affecting children, including:
- Normal and abnormal descent of the testis, with the aim of understanding the mechanism and providing possible non-surgical treatment - Project Leader: John Hutson
- Normal and abnormal postnatal germ cell development, which is believed to be the key to preventing infertility and testicular cancer in men with previous undescended testes in childhood - Project Leader : Ruili Li
- The causes of intractable chronic constipation, and the development of novel investigations and novel treatments, including electrical stimulation - Project Leader: Bridget Southwell
- The cause of duodenal atresia, using a new knockout mouse with downregulation of FGF10 - Project Leader: Warwick Teague
- Novel treatments for colorectal disorders such as anorectal anomalies and Hirschsprung disease - Project Leader: Sebastian King
- Using state-of-the-art manometry to understand surgical problems in the gut, such as oesophageal atresia and Hirschsprung disease - Project Leader: Sebastian King
- Prof John Hutson - Chair of Paediatric Surgery/MCRI Hon Fellow
- A/Prof Warwick Teague - General Surgeon/MCRI Fellow
- Mr Sebastian King - General Surgeon/MCRI Fellow
- Dr Bridget Southwell - Group Leader Surgical Research Group MCRI
- Dr Ruili Li - Scientist, Surgical Research Group
- Dr Jaya Vikramen - PhD student
- Ms Julie Jordan-Ely, Master Student
- National Health & Medical Research Council
- Royal Children's Hospital Foundation
- Murdoch Children's Research Institute
- G-I Therapies
- Hutson JM, Southwell BR, Li R, Lie G, Ismail K, Harisis G, Chen C. The regulation of testicular descent and the effects of cryptorchidism. Endocr Rev. 2013 23(5): 725-52.
This summarises all our recent results into the hormonal regulation of testicular descent and cryptorchidism, and will enable all our work to be widely available, especially to endocrinologists.
- Hutson JM, Li R, Southwell BR, Petersen BL, Thorup J, Cortes. Germ cell development in the postnatal testis; the key to prevent malignancy in cryptorchidism. Front Endocrinol (Lausanne) 2013 3: 176. This shows our recent work on postnatal germ cell development from our current grant.
- Faure, A. Atkinson, J. Bouty, A. O'Brien, M. Levard, G. Hutson, J. Heloury, Y. DICER1 pleuropulmonary blastoma familial tumour predisposition syndrome: What the paediatric urologist needs to know. J Pediatr Urol. 2015
- Thorup J, Kvist K, Clasen-Linde E, Hutson JM, Cortes D. Serum inhibin-B values in boys with unilateral vanished testis and in boys with unilateral cryptorchidism. J Urol. 2014 193(5): 1632-6. Increase of the serum inhibin-B was found to be explained by the contralateral testicular hyperplasia in unilateral vanished testis.
- Cunha GR, Sinclair A, Risbridger G, Hutson JM, Baskin LS. Current understanding of hypospadias relevance of animal models. Nature Reviews Urology 2015 12(5): 271-80. This paper presents the evidence for essential role of oestrogen in distal urethral development and hypospadias.
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