Targeting the Lymphatics in colorectal Liver metastasis
Surgery is the only potentially curative treatment of colorectal liver metastases (CRLM). Lymphatic tumoural spread influences survival, studies from our group have shown that the patterns of lymphatic invasion may be associated with prognosis.
Our clinical studies show that patients with low lymphatic densities in resected tumours demonstrated a significant increase in disease free survival compared to patients with high lymphatic vessel density.
Our current project looks at measuring amounts of lymphangiogenesis (LyA) specific markers in tumour tissue/blood using microRNA techniques in patients with CRLM and correlation with prognosis.
- Professor Christopher Christophi, Head of department
- Dr Marcos Perini, Junior Consultant, Senior Lecturer
- Dr Linh Nguyen, Postdoctoral Research Fellow
- Dr Edith Gomez, Research Assistant
- Christophi C, Nguyen L, Muralidharan V, Nikfarjam M, Banting J. “Lymphatics and colorectal liver metastases: the case for sentinel node mapping”. HPB (Oxford) 2013.
- Muralidharan V, Nguyen L, Banting J, Christophi C. “The prognostic significance of lymphatics in colorectal liver metastases”. HPB Surg. 2014;2014:954604.
- Hadj AK, Malcontenti-Wilson C, Nikfarjam M, Christophi C. Lymphatic patterns of colorectal liver metastases. The Journal of surgical research. 2012;173(2):292-8.