Guangzhou Twin Eye Study

Project Details

The Guangzhou Twin Registry is a population-based registry of twins residing in Guangzhou City. The initial registry database included 9,700 pairs of young twins recruited from the Official Household Registry of Guangzhou City. The registry is designed to provide a resource to identify the genetic and environmental causes of common diseases with an initial focus on eye diseases. From 2006 onward, phenotype and DNA collection have been completed for more than 1,200 twin pairs and their parents or siblings. Most of the young twins have come back for an annual examination of the progressive traits, such as refraction, ocular biometry, weight, and height for 10 years. Genome-wide association scans have been completed recently. This twin cohort with annual visit data for more than 10 years will provide unique opportunities for genetic research and predictive medicine.


Dr Xiaohu Ding, research fellow

Dr Xiaobo Guo, senior statistician

Dr Yanxian Chen, PhD student

Ms Sally Xie, research coordinator


Prof David Mackey, Lions Eye Institute, University of Western Australia

Prof Ian Morgan, Research School of Biology, Australian National University


National Natural Science Foundation, China
Fundamental Research Funds of the State Key Laboratory in Ophthalmology

Research Outcomes

1. Wang D, Liu B, Huang S, Huang W, He M. Relationship between refractive error and ocular biometrics in twin children: the Guangzhou Twin Eye Study. Eye Sci. 2014 Sep;29(3):129-33.

2.Yan X, Congdon N, Zhang J, Chen Q, Guo X, He M. No Evidence for Genetic Contribution of Ocular Dominance: The Guangzhou Twin Eye Study. Asia Pac J Ophthalmol (Phila). 2014 Jan-Feb;3(1):32-5

3.Ding X, Wang D, Huang Q, Zhang J, Chang J, He M. Distribution and heritability of peripheral eye length in Chinese children and adolescents: the Guangzhou Twin Eye Study. Invest Ophthalmol Vis Sci. 2013 Feb 5;54(2):1048-53.

4.Zheng Y, Huang W, Zhang J, He M. Phenotypic and genetic correlation of blood pressure and body mass index with retinal vascular caliber in children and adolescents: the Guangzhou twin eye study. Invest Ophthalmol Vis Sci. 2013 Jan 17;54(1):423-8

5.Zheng Y, Ding X, Chen Y, He M. The Guangzhou Project: An Update. Twin Res Hum Genet. 2013 Feb;16(1):73-8

6.Shen P, Ding X, Zheng Y, Congdon NG, He M. Contribution of genetic and environmental effects on lens thickness: the Guangzhou Twin Eye study. Invest Ophthalmol Vis Sci. 2012 Apr 2; 53(4):1758-63.

7.Ding X, Lin Z, Huang Q, Zheng Y, Congdon N, He M. Heritability of peripheral refraction in Chinese children and adolescents: the Guangzhou Twin Eye study. Invest Ophtahlmol Vis Sci. 2012 Jan 10; 53(1): 107-11.

8.Zhang J., Hur Y.-M., Huang W., Ding X., Feng K., He M. Shared genetic determinants of axial length and height in children: The Guangzhou twin eye study. Arch Ophthalmol. 2011 Jan;129(1):63-8.

Research Group

Ophthalmic Epidemiology Group

Faculty Research Themes

Child Health

School Research Themes

Child Health in Medicine, Critical Care

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre


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