ZOC-BHVI High Myopia Cohort Study

Project Details

The increasing prevalence of high myopia and its associated pathologies has raised challenges to ophthalmic services. This project aims to explore the onset and progression of myopic pathologies in highly myopic eyes through a prospective research cohort established in South China.

A total of 890 patients aged 7-70 years old with high myopia (sphere  < -6.00D) visiting the optometric clinic of Zhongshan Ophthalmic Center (ZOC) were invited to participate in the baseline examinations and follow-up visit  over a 10 year period. People having secondary myopia, history of any refractive surgery, significant ocular media opacity, or other severe health problems were excluded. The measurements included visual acuity, ocular biometry, visual function, cycloplegic refraction, fundus imaging, ocular shape by MRI, blood tests and questionnaires.

Specific Aims of Project included:
1)To determine the development patterns of pathologies in highly myopic eyes, such as MMD, MRS, CNV and posterior staphyloma.
2)To explore possible risk factors of pathological changes in highly myopic eyes.
3)To identify the risk of developing pathologies in acquired high myopia.
4)To develop a risk prediction system for the onset and progression of major pathologies, such as MMD, based on evidences from natural history, environmental and genetic risk factors.


Dr Xinxing Guo, PhD student

Dr Xiaohu Ding, research fellow

Dr Xiaobo Guo, senior statistician

Dr Yanxian Chen, PhD student

Ms Sally Xie, research coordinator


Prof Ian Morgan, Research School of Biology, Australian National University

Prof Kyoko Ohno-Matsui, Tokyo Medical and Detal University, Japan


National Natural Science Foundation, China
Fundamental Research Funds of the State Key Laboratory in Ophthalmology
Brien Holden Vision Institute, Australia

Research Outcomes

1. Ding X, Chang RT, Guo X, Liu X, Johnson CA, Holden BA, He M. Visual field defect classification in the Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Registry Study.Br J Ophthalmol. 2016 Mar 31. pii: bjophthalmol-2015-307942.

Research Group

Ophthalmic Epidemiology Group

Faculty Research Themes

Infection and Immunology

School Research Themes

Critical Care

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre


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