RoBiN (Risk of Breast Neoplasia): An acceptability and feasibility study of personalised screening
Project Details
The RoBiN study, endorsed by BreastScreen Victoria (BSV) aims to provide Australian women aged 40-59 with a personalised approach to breast cancer screening by offering a risk assessment which incorporates major known breast cancer risk factors (family history, mammographic breast density [MBD], and a polygenic risk score [PRS]). The multifactorial risk assessment and/or MBD will be used to tailor subsequent screening recommendations based on the individual’s personal risk of developing breast cancer as an alternative to the current population-based age-stratified approach.
Clinical and genomic risk factors will be combined to calculate 10-year and lifetime risk of breast cancer using the validated BRISK model. The calculated risk will be mapped onto risk categories defined by Cancer Australia and used to tailor supplemental and subsequent breast cancer screening. Participants and a nominated general practitioner (GP) or practice clinic will receive a risk report summarising their breast cancer risk, recommendations for any supplemental screening or changes to frequency of subsequent screening.
This acceptability and feasibility study will explore the acceptability and feasibility of using this approach to conduct risk-stratified breast cancer screening within BSV, as well as piloting the intervention and procedures to inform the design of future larger implementation trials.
Researchers
Dr Dulashi (Anna) Withanage Dona, Research Lead, The University of Melbourne
Herman Prof Jon Emery, Academic GP, University of Melbourne
Dr Sibel Saya, Research Fellow/ Genetic Counsellor, The University of Melbourne
Dr Sue Malta, Qualitative Health Researcher, The University of Melbourne
A/Prof Justin Tse, Academic GP, The University of Melbourne & Cancer Council Victoria
Ms. Georgia Ramsay, Research Assistant, University of Melbourne
Ms. Madeline Luke, Research Assistant, University of Melbourne
Collaborators
A/Prof Jennifer Stone, Epidemiologist, The University of Western Australia
Dr. Daniel Lee, Radiologist, Imaging Associates
A/Prof Helen Frazer, Epidemiologist and Radiologist, St Vincent's Hospital Melbourne & BreastScreen Victoria
Dr. Erika Spaeth Tuff, Genetic Scientist, Phenogen Sciences/Genetic Technologies
Ms Cindy Schultz Ferguson, Consumer Investigator, My Breast cancer RISK (MyBRISK) NHMRC Centre of Research Excellence/ The University of Melbourne
Ms. Sally Doncovio, Research and Policy Manager, BreastScreen Victoria
Mrs. Sue Macaulay, Director Quality and Clinical Care, BreastScreen Victoria
Ms. Nikki Davis, Consumer Investigator, Primary Care Collaborative Cancer Clinical (PC4) Trials Group
Funding
RoBiN is a collaboration with My Breast cancer RISK (MyBRISK) Centre of Research Excellence at The University of Melbourne, BreastScreen Victoria, our study investigators and partner organisations. This study is funded by the National Health and Medical Research Council (NHMRC).
Research Group
Cancer in Primary CareFaculty Research Themes
School Research Themes
Cancer in Medicine, Critical Care
Key Contact
For further information about this research, please contact the research group leader.
Department / Centre
General Practice and Primary Care
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