David O'Neal
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Group Leader
Professor David O'NealDTRG-t1research@unimelb.edu.au
Research Overview
Professor David O’Neal leads his own research group based at the University Of Melbourne, Department Of Medicine at St Vincent’s Hospital. He has led studies with significant national and international collaborations involving clinicians, academics and industry. In addition to planning his own investigator- initiated studies he has provided input into study design of commercially sponsored studies which his team has conducted. The DTRG are proudly partnering with The Australian Centre for Accelerating Diabetes Innovations (ACADI) and have three collaborative projects which will be undertaken in the coming years.
The DTRG Mission is to improve the lives of people with diabetes through exceptional research that drives advancement in innovative technologies. Their vision is to be the centre of excellence in Adult Type 1 diabetes technology research in Australia and the leading partner for collaborators, participants, industry and key stakeholders.
Our group received the University of Melbourne 2020 MDHS Award for Excellence in Team-Based Research Programs for working nationally and internationally with and for people living with Type 1 diabetes to improve their health outcomes.
Further information about our research can be found on the DTRG website
Staff
Professor David O’Neal, Head of D.T.R.G Principal Investigator
Professor Alicia Jenkins, Principal Investigator
Catriona Sims, Project Portfolio Manager
Dr Jean Lu, Clinical Physician (PHD Candidate)
Dr Melissa Lee, Clinical Physician (PHD)
Dr Barbora Paldus, Clinical Physician (PHD)
Dr Balasubramanian Krishna Murthy, Clinical Physician
Dr Georgina Manos, Research Fellow
Dr Bella Hallim, Research Fellow
Varuni Obeyesekere, Scientist
Katie Brown, Clinical Research Co-ordinator
Dr Dale Morrison, Clinical Research Co-ordinator, Exercise Physiologist
Lesley Robinson, Clinical Research Co-ordinator, Credentialed Diabetes Educator
Emma Netzer, Clinical Research Co-ordinator, Credentialed Diabetes Educator
Steve Flint, Clinical Research Co-ordinator, Dietitian
Lisa Lu, Clinical Research Nurse
Tehitena Bekele, Clinical Research Nurse
Lachlan Christian, Project Assistant, Website and Data Management
Collaborators
Funding
Juvenile Diabetes Research Foundation International
Juvenile Diabetes Research Foundation Australia
Helmsley Charitable Trust
St Vincent's Hospital Melbourne Research Endowment Fund
Diabetes Australia Research Program
Research Publications
Morrison D, Zaharieva DP, Lee MH, Paldus B, Vogrin S, Grosman B, Roy A, Kurtz N, O'Neal DN. Comparable Glucose Control with Fast-Acting Insulin Aspart Versus Insulin Aspart Using a Second-Generation Hybrid Closed-Loop System During Exercise. Diabetes Technol Ther. 2022;24:93-101
Trawley S, Stephens AN, McAuley SA, Speight J, Hendrieckx C, Vogrin S, Lee MH, Paldus B, Bach LA, Burt MG, Cohen ND, Colman PG, Davis EA, Holmes-Walker DJ, Jenkins AJ, Kaye J, Keech AC, Kumareswaran K, MacIsaac RJ, McCallum RW, Sims CM, Stranks SN, Sundararajan V, Ward GM, Jones TW, O'Neal DN. Driving with type 1 diabetes: real-world evidence to support starting glucose level and frequency of monitoring during journeys. Diabetes Technol Ther. 2022
Paldus B, Morrison D, Zaharieva DP, Lee MH, Jones H, Obeyesekere V, Lu J, Vogrin S, La Gerche A, McAuley SA, MacIsaac RJ, Jenkins AJ, Ward GM, Colman P, Smart CEM, Seckold R, King BR, Riddell MC, O'Neal DN. A Randomized Crossover Trial Comparing Glucose Control During Moderate-Intensity, High-Intensity, and Resistance Exercise With Hybrid Closed-Loop Insulin Delivery While Profiling Potential Additional Signals in Adults With Type 1 Diabetes. Diabetes care. 2022; 45:194-203
McAuley SA, Trawley S, Vogrin S, Ward GM, Fourlanos S, Grills CA, Lee MH, Alipoor AM, O'Neal DN, O'Regan NA, Sundararajan V, Colman PG, MacIsaac RJ. Closed-Loop Insulin Delivery Versus Sensor-Augmented Pump Therapy in Older Adults With Type 1 Diabetes (ORACL): A Randomized, Crossover Trial. Diabetes Care. 2022; 45:381-390
Kong YW, Venkatesh N, Paldus B, Lee MH, Zhu J, Sawyer M, Chakrabarti A, Uren C, MacIsaac R, Jenkins A, O'Neal DN. Upload and Review of Insulin Pump and Glucose Sensor Data by Adults with Type 1 Diabetes: A Clinic Audit. Diabetes Technol Ther. 2022
Venkatesh N, Astbury N, Thomas MC, Rosado CJ, Pappas E, Krishnamurthy B, MacIsaac RJ, Kay TWH, Thomas HE, O'Neal DN. SARS-CoV-2 as a Potential Cause of Type 1 Diabetes Facilitated by Spike Protein Receptor Binding Domain Attachment to Human Islet Cells: An Illustrative Case Study and Experimental Data. Diabet Med. 2021:e14608
Paldus B, Lee MH, Morrison D, Zaharieva DP, Jones H, Obeyesekere V, Lu J, Vogrin S, LaGerche A, McAuley SA, MacIsaac RJ, Jenkins AJ, Ward GM, Colman P, O'Neal DN. First Randomized Controlled Trial of Hybrid Closed Loop Versus Multiple Daily Injections or Insulin Pump using Self-Monitoring of Blood Glucose in Free-Living Adults with Type 1 Diabetes Undertaking Exercise. Journal of diabetes science and technology. 2021;15:1399-1401
McAuley SA, Vogrin S, Lee MH, Paldus B, Trawley S, de Bock MI, Abraham MB, Bach LA, Burt MG, Cohen ND, Colman PG, Davis EA, Hendrieckx C, Holmes-Walker DJ, Jenkins AJ, Kaye J, Keech AC, Kumareswaran K, MacIsaac RJ, McCallum RW, Sims CM, Speight J, Stranks SN, Sundararajan V, Ward GM, Jones TW, O'Neal DN, Australian JC-LRG. Less Nocturnal Hypoglycemia but Equivalent Time in Range Among Adults with Type 1 Diabetes Using Insulin Pumps Versus Multiple Daily Injections. Diabetes Technol Ther. 2021;23:460-466
Lu JC, Vogrin S, McAuley SA, Lee MH, Paldus B, Bach LA, Burt MG, Clarke PM, Cohen ND, Colman PG, de Bock MI, Jane Holmes-Walker D, Jenkins AJ, Kaye J, Keech AC, Kumareswaran K, MacIsaac RJ, McCallum RW, Roem K, Sims C, Stranks SN, Trawley S, Ward GM, Sundararajan V, Jones TW, O'Neal DN, Australian JC-LRG. Meal-time glycaemia in adults with type 1 diabetes using multiple daily injections vs insulin pump therapy following carbohydrate-counting education and bolus calculator provision. Diabetes Res Clin Pract. 2021;179:109000.
Lee MH, Paldus B, Vogrin S, Morrison D, Zaharieva DP, Lu J, Jones HM, Netzer E, Robinson L, Grosman B, Roy A, Kurtz N, Ward GM, MacIsaac RJ, Jenkins AJ, O'Neal DN. Fast-Acting Insulin Aspart Versus Insulin Aspart Using a Second-Generation Hybrid Closed-Loop System in Adults With Type 1 Diabetes: A Randomized, Open-Label, Crossover Trial. Diabetes care. 2021
Zaharieva D, Teng JH, Ong ML, Lee MH, Paldus B, Jackson L, Holihan CA, Shub A, Tipnis S, Cohen O, O'Neal DN, Krishnamurthy B: Title: Continuous Glucose Monitoring Versus Self-Monitoring of Blood Glucose to Assess Glycemia in Gestational Diabetes. Diabetes Technol Ther 2020; DOI: 10.1089/dia.2020.0073.
Venkatesh N, Paldus B, Lee MH, MacIsaac RJ, Jenkins AJ, O'Neal DN: COVID-19, Type 1 Diabetes Clinical Practice, Research, and Remote Medical Care: A View From the Land Down-Under. Journal of Diabetes Science and Technology 2020, 14:803-4
McAuley SA, Lee MH, Paldus B, Vogrin S, de Bock MI, Abraham MB, Bach LA, Burt MG, Cohen ND, Colman PG, Davis EA, Hendrieckx C, Holmes-Walker DJ, Kaye J, Keech AC, Kumareswaran K, MacIsaac RJ, McCallum RW, Sims CM, Speight J, Stranks SN, Sundararajan V, Trawley S, Ward GM, Jenkins AJ, Jones TW, O'Neal DN, Australian JC-LRG: Six Months of Hybrid Closed-Loop Versus Manual Insulin Delivery With Fingerprick Blood Glucose Monitoring in Adults With Type 1 Diabetes: A Randomized, Controlled Trial. Diabetes Care 2020, 43:3024-33
Lee MH, Vogrin S, Paldus B, Jayawardene D, Jones HM, McAuley SA, Obeyesekere V, Gooley J, La Gerche A, MacIsaac RJ, Sundararajan V, Jenkins AJ, Ward GM, O'Neal DN: Glucose and Counterregulatory Responses to Exercise in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia Using Closed-Loop Insulin Delivery: A Randomized Crossover Study. Diabetes Care 2020, 43:480-3
Zaharieva DP, Messer LH, Paldus B, O’Neal DN, Maahs DM and Riddell MC (2020), Glucose control during physical activity and exercise using closed loop technology in type 1 diabetes, Canadian Journal of Diabetes
Venkatesh N, Paldus B, et al. (2020) COVID-19, Type 1 Diabetes Clinical Practice, Research, and Remote Medical Care: A View From the Land Down-Under., Journal of Diabetes Science and Technology, vol 14, no 4, pp 803-804
Morrison D, et al, (2020), Kinetics of Continuously Measured Interstitial Versus Venous Lactate Following High Intensity Exercise in Adults With Type 1 Diabetes, Diabetes Technology & Therapeutics, Vol. 22. 140
Zaharieva D, Teng JH, Ong ML, Lee MH, Paldus B, Jackson L, Holihan CA, Shub A, Tipnis S, Cohen O, O'Neal DN, Krishnamurthy B, (2020), Continuining glucose monitoring versus self-monitoring of blood glucose to assess glycemia in gestational diabetes, Diabetes Technol Ther, Apr 23
Paldus B, Lee MH, Jones HM, et Al, (2019), Glucose Control Using a Standard Versus an Enhanced Hybrid Closed Loop System: A Randomized Crossover Study, Diabetes Technol Ther. 21(1):56-58
Paldus B, Zaharieva D, (2019), D-I-Y Pancreas, Diabetes Management Journal May 2019
Lee MH, Vogrin S, Paldus B, et al, (2019), Glucose and Counterregulatory Responses to Exercise in Adults with Type 1 Diabetes and Impaired Awareness of Hypoglycemia Using Closed-Loop Insulin Delivery: A Randomized Crossover Study, Diabetes Care, 43. dc191433. 10.2337/dc19-1433
Lee MH, Vogrin S, Paldus B, et al, (2019), Glucose Control in Adults with Type 1 Diabetes Using Medtronic Prototype Enhanced-Hybrid Closed-Loop System: A Feasibility Study, Diabetes Technol Ther, 21(9):499-506. doi:10.1089/dia.2019.0120
Lee MH, Paldus B, Krishnamurthy B, et al, (2019), The Clinical Case for the Integration of a Ketone Sensor as Part of a Closed Loop Insulin Pump System, J Diabetes Sci Technol. January: 1932296818822986. doi:10.1177/1932296818822986
Paldus B, Lee MH, O’Neal DN, (2018), Insulin Pumps in General Practice, Australian Prescriber, 41. 186-190. 10.18773/austprescr.2018.056.
McAuley SA, de Bock MI, Sundararajan V, Lee MH, Paldus B, Ambler GR, Bach LA, Burt MG, Cameron FJ, Clarke PM, Cohen ND, Colman PG, Davis EA, Fairchild JM, Hendrieckx C, Holmes-Walker DJ, Horsburgh JC, Jenkins AJ, Kaye J, Keech AC, King BR, Kumareswaran K, MacIsaac RJ, McCallum RW, Nicholas JA, Sims C, Speight J, Stranks SN, Trawley S, Ward GM, Vogrin S, Jones TW, O'Neal DN, (2018), Effect of 6 months of hybrid closed-loop insulin delivery in adults with type 1 diabetes: A randomised controlled trial protocol, BMJ open, 8. e020274. 10.1136/bmjopen-2017-020274
Lee MH, Paldus B, O’Neal DN, (2017), Type 1 diabetes and the Artificial Pancreas, Diabetes Management Journal