Synovial Knee Arthritis Research (SKAR)
Osteoarthritis is the most common form of arthritis affecting the knee, followed by rheumatoid arthritis and both of these diseases cause disability and chronic pain. While total knee joint replacement is effective for end stage disease methods to improve pain and reduce inflammation may reduce the need for surgery. This research aims to investigate the role of of granulocyte macrophage-colony stimulating factor (GM-CSF,) previously implicated in inflammatory arthritis , and its link to knee OA. Tissue samples from patients undergoing total knee replacement will be compared to samples from patients with non arthritic knees undergoing arthoscopy to investigate for the presence of GM-CSF.