Musculoskeletal

Musculoskeletal diseases are identified as the second greatest cause of disability throughout the world and include conditions such as osteoporosis, sarcopenia and arthritis. Researchers are part of cross-functional and collaborative teams to study conditions related to disorders of the bone, muscle and joint for improvement in disease prevention and evidence-based care.

Groups / Projects Research Lead Dept / Centre
@AgeMelbourne Professor Andrea B Maier
Medicine and Radiology
A computer-aided decision system for gait analysis Project Leader Dr Morgan Sangeux Paediatrics
Advanced Limb Reconstruction Head of Department of Surgery,
St. Vincent's Hospital,
Professor Peter Choong

Surgery
An ultrasensitive assay to detect aggrecan degradation products in patient fluids Project Leader Professor Amanda Fosang Paediatrics
Analysis of synovial fluid and peripheral blood samples from patients with rheumatoid arthritis and using patients with osteoarthritis as controls. Associate Professor Keith Lim Medicine and Radiology
Arthritis Research Group Laboratory Head Professor Amanda Fosang
Paediatrics
BioFabrication of the osteo-chondral interface using multimodal 3D bioprinting Professor Peter Choong Surgery
Bioink development for cartilage tissue engineering Dr Romane Blanchard
Dr Cathal O’Connell
Surgery
Biological mechanisms underpinning the social gradient of health Principal Fellow A/Prof Sharon Brennan-Olsen
Western Health
Bone and Mineral Research Group Group Leader Professor John D Wark
Medicine and Radiology
Bone strength in young healthy females, older patients with low-trauma fracture and older healthy adults: peripheral quantitative computed tomography based finite element analysis Group Leader Prof. John D Wark Medicine and Radiology
Bone Substrate Composition Affecting Bone Cell Formation, Function and Bone Turnover Associate Professor Damian Myers Medicine and Radiology
Characterization of Osteosarcopenia in Older Persons: A Bench to Bedside Approach Characterization of Osteosarcopenia in Older Persons: A Bench to Bedside Approach Dr David Scott Medicine and Radiology
Cognitive Health Group Leader Professor Cassandra Szoeke Medicine and Radiology
Cognitive impairment and its interference with Activities of Daily Living Dr Julian Sacre Medicine and Radiology
Community engagement and policy discourse: Musculoskeletal disease Principal Fellow A/Prof Sharon Brennan-Olsen
Western Health
Controlled mechanical stimulation for cartilage regeneration modelling with 3D bioprinting techniques Dr Carmine Onofrillo
Dr Serena Duchi
Surgery
Design of tensile strength tests for very soft materials Dr Cathal O’Connell
Dr Romane Blanchard
Surgery
Determining the role of CCL17 in arthritis and inflammation A/Prof Andrew Cook Medicine and Radiology
Development and characterisation of an animal model of neurological heterotopic ossification Dr Rhys Brady Medicine and Radiology
Development of a Minimally Invasive Chronic Neural Interface Group Leaders Dr Nicholas Opie and Dr Thomas Oxley Medicine and Radiology
Development of mechanical testing protocols for very soft tissues Dr Cathal O’Connell
Dr Romane Blanchard
Surgery
Diffusion properties in hydrogel materials Dr Cathal O’Connell
Dr Romane Blanchard
Surgery
Dynamic microfluidic in vitro differentiation of stem cells for cartilage regeneration in surgical 3D bioprinting Dr Carmine Onofrillo
Dr Serena Duchi
Surgery
Effects of Vitamin D Status on DEXA Femoral Neck BMD in Children and Adolescents A/Prof Christine Rodda Medicine and Radiology
Effects of Vitamin D Status on Forearm Fracture Healing Rates in Children and Adolescents: A Pilot Study Associate Professor Christine Rodda Medicine and Radiology
Elucidating molecular signalling pathways controlled by anti-inflammatory steroids Dr Adrian Achuthan Medicine and Radiology
Elucidating molecular signalling pathways controlled by anti-inflammatory steroids Dr Adrian Achuthan Medicine and Radiology
Elucidating the Effect of Hyperglycaemia (Short and Long Term) on Bone and Muscle Quality and Metabolism Associate Professor Itamar Levinger Medicine and Radiology
EMPOWER the power of human muscle Prof. Kwang Lim Medicine and Radiology
Evaluating the impact of obesity on knee load over time in those who have undergone optimal surgical re-alignment after total knee replacement Professor Peter Choong Surgery
Gait, Cognition and Decline (The GOOD Project) Professor Gustavo Duque Medicine and Radiology
Generation of an ex vivo regeneration model for 3D bioprinting applications Dr Carmine Onofrillo
Dr Serena Duchi
Surgery
GM-CSF-mediated molecular signalling pathways contributing to inflammation Dr Adrian Achuthan Medicine and Radiology
HDAC6 inhibitors as a treatment for Rett syndrome: Resolving neuronal trafficking deficits Dr Nicole Van Bergen
Professor John Christodoulou
Paediatrics
Healthy Ageing Program Group Leader Professor Cassandra Szoeke
Medicine and Radiology
Hugh Williamson Gait Laboratory/Orthopaedic Department Research Group Leader Professor Kerr Graham
Paediatrics
Identifying novel cartilage proteins with new functions Project Leader Professor Amanda Fosang Paediatrics
Imaging Group Leader Professor Cassandra Szoeke Medicine and Radiology
In Vivo Tibiofemoral Biomechanics in Healthy Adults During Functional Activity Dr Hans Gray Surgery
Investigating lipotoxic impacts of fatty acid synthesis on: (1) osteoblasts, and (2) osteoclast, in vitro and (3) Skeletal Muscle Associate Professor Damian Myers Medicine and Radiology
Investigating the effects of GM-CSF and M-CSF derived human macrophages on phagocytosing P. falciparum infected erythrocytes and cytokine production Dr Adrian Achuthan Medicine and Radiology
Investigating the neural mechanisms of androgen action in the regulation of the musculoskeletal system. Project Lead Associate Professor Rachel Davey Medicine and Radiology
Is muscle surgery or bone surgery better for young children with cerebral palsy who have hip displacement? The Cerebral Palsy Hip Interventions Project (CP-HIP) Project Leader Dr Kate Willoughby Paediatrics
Lifestyle and Prevention Group Leader Professor Cassandra Szoeke Medicine and Radiology
Mental Health Group Leader Professor Cassandra Szoeke Medicine and Radiology
Mice resistant to collagen degradation teach us about skeletal development and arthritis Project Leader Professor Amanda Fosang Paediatrics
Mid-Thigh Bone and Muscle Mass Measurements as an Assessment Tool for Diagnosis of Osteoporosis/penia, Sarcopenia and Osteosarcopenia: A Longitudinal Validation Study Dr Ebrahim Bani Hassan Medicine and Radiology
Mindfulness, cognitive processes and coping in chronic illness: insights from a study of joint replacement surgery Professor Peter Choong Surgery
Molecular signalling pathways controlling gene expression during chronic disease progression Dr Adrian Achuthan Medicine and Radiology
Molecular signalling pathways controlling gene expression during chronic disease progression Dr Adrian Achuthan Medicine and Radiology
Multimedia (MyStay) Intervention for managing patient experience (MIME) following total hip replacement surgery: a cluster randomised trial. Ms Jo McDonall Surgery
Multimorbidity in Ageing Group Leader Professor Cassandra Szoeke Medicine and Radiology
Musculoskeletal and Bone Health Group Leader Professor Cassandra Szoeke Medicine and Radiology
Musculoskeletal Health: Associations with Inflammation and Social Determinants in Young Adults Dr. Sharon Brennan Medicine and Radiology
Novel biological marker combinations to determine physical biological age Dr Camilla Tuttle Medicine and Radiology
Optimising Recovery Following Fracture in Older Adults – What Does the Evidence Tell Us? A/Professor Kerrie Sanders Medicine and Radiology
Osteosarcopenia in Older Adults Attending a Fracture Liaison Service Dr David Scott Medicine and Radiology
Outcomes of Hip Interventions for Children with Cerebral Palsy – An International, Multi-Centre Prospective, Comparative Cohort Study Project Leader Dr Kate Willoughby Paediatrics
Postoperative Quality of Recovery Co-director Colin Royse
Surgery
Pre-clinical Analysis of Effects of Lamin A Overexpression on Mesenchymal Stem Cell Differentiation into Myocytes Associate Professor Damian Myers Medicine and Radiology
Pre-Clinical Studies Identifying Novel Molecular Regulators of Skeletal Muscle Growth and Atrophy Professor Alan Hayes Medicine and Radiology
Predicting outcomes for people with knee osteoarthritis in general practice Prof Jane Gunn
A/Prof Michelle Dowsey
General Practice
Probing the complexity of cartilage using the Atomic Force Microscope Dr Cathal O’Connell
Dr Romane Blanchard
Surgery
Quality of Life Group Leader Professor Cassandra Szoeke Medicine and Radiology
Quantitative Measure of Effusions Associate Professor Keith Lim Medicine and Radiology
Re-Purposed Pharmacological Agents for Rapid Therapeutic Translation in Duchenne Muscular Dystrophy Professor Alan Hayes Medicine and Radiology
Refining the comprehensive geriatric assessment Prof. Kwang Lim Medicine and Radiology
Reproductive Steroids Research Group Group Leader Professor Mathis Grossmann, MD, PhD, FRACP
Medicine and Radiology
Research at Epworth Professor Richard de Steiger
Rheumatology Group Leader Associate Professor Keith Lim
Medicine and Radiology
Single Event Multilevel Surgery in Bilateral Spastic Cerebral Palsy: A Multi-centre, Long-term, Follow-up Study Project Leader Dr Pam Thomason Paediatrics
Social determinants of musculoskeletal disease across the lifecourse Principal Fellow A/Prof Sharon Brennan-Olsen
Western Health
Sternal ultrasound assessment of plate vs. wire fixation Prof Alistair Royse Surgery
Structural biology of proteins involved in bone diseases Dr Brett Bennetts Medicine and Radiology
Surgery Research Surgery
Synovial Knee Arthritis Research (SKAR) Professor John Hamilton Surgery
The actions of the male sex hormone, testosterone, to decrease fat mass. Project Lead Associate Professor Rachel Davey Medicine and Radiology
The Arthroplasty and Bariatric Surgery (ABS) Study: a randomised controlled trial of laparoscopic adjustable gastric banding prior to total knee arthroplasty Professor Peter Choong Surgery
The blood pressure drop makes you fall Dr. Julian Sacre Medicine and Radiology
The CGA Study: Development of an evidence based Comprehensive Geriatric Assessment Professor Andrea B Maier Medicine and Radiology
The Correlation between Knee Effusions and Clinical Presentation in Patients with Knee Osteoarthritis Associate Professor Keith Lim Medicine and Radiology
The Effect of Antidepressants on Human Mesenchymal Stem Cell Osteogenesis and Adipogenesis Professor Gustavo Duque Medicine and Radiology
The effect of epilepsy on bone Dr Rhys Brady Medicine and Radiology
The Gait Outcomes Assessment List (GOAL): Validation of a new measure of gait function for children with cerebral palsy Project Leader Dr Pam Thomason Paediatrics
The intra-individual rate of ageing Prof. Andrea Maier Medicine and Radiology
The MARKA Study: Maximum Acceptable Risk of complication in total Knee Arthroplasty Dr Michelle Dowsey Surgery
The role of a novel GM-CSF-CCL17 pathway in osteoarthritis A/Prof Andrew Cook Medicine and Radiology
The role of an aggrecan 32mer fragment in developing osteoarthritis Project Leader Professor Amanda Fosang Paediatrics
The SHAPE Study: Nutritional Needs, Physical Function and Sarcopenia in Geriatric Outpatient Project Lead Professor Andrea B Maier Medicine and Radiology
Towards a biological geriatric assessment Dr. Camilla Tuttle Medicine and Radiology
Type I interferon regulation of macrophage metabolism and activation Dr Andrew Fleetwood Medicine and Radiology
Type I interferon regulation of macrophage metabolism and activation Dr Andrew Fleetwood Medicine and Radiology
Understanding Patient Capacity to Adhere to Prescribed Treatment Regime Post-Fracture Dr. Sharon Brennan Medicine and Radiology
Understanding the effect of lower limb torsional deformities in typically developing children and adolescents Project Leader Dr Morgan Sangeux Paediatrics
Using health-related quality of life scores as predictor of outcomes and to advance health economic evaluation methodologies in lower limb arthroplasty patients Michelle Dowsey
Philip Clarke
Surgery
Using Wearable Activity Trackers to Monitor Physical Activity in Older Adults Undergoing Exercise Interventions for Falls Dr David Scott Medicine and Radiology
Vascular Health Group Leader Professor Cassandra Szoeke Medicine and Radiology
Vitamin D deficiency and balance Professor Cassandra Szoeke Medicine and Radiology
What controls the development of strong cortical bone? A/Prof Natalie Sims Medicine and Radiology
Women's Healthy Ageing Project Group Leader Professor Cassandra Szoeke Medicine and Radiology

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