Translational Neurogentics Laboratory
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Lead: Professor Michael Hildebrand The Translational Neurogenetics Laboratory, led by Professor Michael Hildebrand aims to uncover the genetic and neurobiological mechanisms of epilepsy, speech disorders, and vascular malformations, and to translate this knowledge into improved patient care. Based within the Epilepsy Research Centre at Austin Hospital, our work spans from basic discovery to clinical application. We are investigating the contribution of somatic mutations to severe focal epilepsy by studying surgical brain tissue and biobanked specimens, applying advanced sequencing methods to identify causal changes. In speech and language disorders, our group has discovered more than 30 genes linked to childhood speech disorders, combining gene discovery with imaging and Crispr mouse models to map the neural pathways involved in human speech. For vascular malformations, we use genetic sequencing to identify targetable mutations and run clinical trials of precision therapies, offering new treatment opportunities for patients in Australia and globally. |
Translational Neurogenetics Team |
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