Elucidating molecular signalling pathways controlled by anti-inflammatory steroids

  • Project Lead

    Dr Adrian Achuthan
    T: +61 3 8344 3298
    E: aaa@unimelb.edu.au
    W: Personal web page

    Location: Dept of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria 3050, Australia.

Project Details

Steroids (glucocorticoids) are widely used to treat the chronic inflammation and pain associated with many diseases such as rheumatoid arthritis and osteoarthritis. Unfortunately, there are side effects associated with usage of glucocorticoids in such diseases. In this project, you will use genome-wide approaches such as microarray to identify the genes that are regulated by glucocorticoids. More specifically you will investigate molecular signalling pathways that lead to activation of transcription factors that lead to differential expression of glucocoritcoid-controlled genes in inflammatory conditions. Enhancing our understanding of molecular signalling pathways that are governed by glucocorticoids may lead to improved clinical therapies with minimal side effects.

Researchers

Research Group

Hamilton Laboratory



Faculty Research Themes

Infection and Immunology



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Medicine and Radiology

Unit / Centre

Hamilton Laboratory