Clinical Pathology Research

Buchanan laboratory: Oncogenomics (colorectal cancer)

Research Program Leader : Dr Daniel Buchanan

The Oncogenomics Group research includes the identification and investigation of clinically and biologically relevant subtypes of colorectal cancer (CRC), including both familial and non-familial CRC, that can be identified through genetic, epigenetic, somatic and histopathological characterisation of CRC tumours and their pre-malignant lesions (polyps).

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Genomics Platform Group

Research Program Leader : Associate Professor Oliver Hofmann

Working on improved scalability and reliability of sequencing workflows, better detection of changes in cancer genomes, and aims to make tumour data, especially molecular data, from medical institutions and other organisations, accessible for research use in real time.


Hollande laboratory: Tumour Heterogeneity in Metastatic Cancer

Research Program Leader : Associate Professor Fred Hollande

Understanding the mechanisms that underlie the genetic and non-genetic heterogeneity within individual tumours, and characterising signalling pathways that specify the differential behaviour of cell subpopulations that drive metastatic progression and treatment response.

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Rare Disease Oncogenomics

Research Program Leader : Dr Richard Tothill

The Rare Disease Oncogenomics (RADIO) laboratory is dedicated to translational research of rare and less common cancers. Our research encompasses neuroendocrine tumours (NET), including tumours of sympathetic tissues (pheochromocytoma and parganglioma) and skin (Merkel cell carcinoma), as well as cancers of unknown primary (CUP).


Southey laboratory: Genetic epidemiology laboratory

Research Program Leader : Professor Melissa Southey

Our research programs are focused on characterising the genetic and epigenetic factors responsible for cancer predisposition and progression, including familial aggregation of cancers.

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