NHMRC Centre for Research Excellence for Reducing the Burden of Colorectal Cancer by Optimising Screening
For every one million Australians 50 years and older, an estimated 80,000 people have been over-screened with colonoscopies and 29,000 people have been under-screened with colonoscopies. The NHMRC has funded a Centre for Research Excellence: Optimising Colorectal Cancer Screening in Primary Care (CRE) to increase risk-stratified screening for colorectal cancer, to reduce the population’s disease burden from colorectal cancer and improve health services delivery.
The CRE is currently bringing together experts in clinical and non-clinical sciences:
- to develop the first personalised Colorectal cancer RISk Prediction tool ('CRISP') that incorporates all known genetic, pathology, family history, lifestyle factors and personal characteristics, and
- to develop proven methods for implementing CRISP in general practice.
The CRE program of research is following the Medical Research Council's Developing and Evaluating Complex Interventions (UK) to develop and validate complex interventions. The CRE will develop an accurate individual risk prediction model relevant to the Australian population, and the Primary Cancer Care team in the Department of General Practice are designing and trialling the risk prediction tool - CRISP – for use in general practice. The tool and model will be validated using data from the Colon Cancer Family Registry, a fully characterized study of both population-based and clinic-based participants measured for known and suspected risk factors including personal characteristics, environmental risk factors, complex family history and measured genetic variants.
Associate Professor Marie Pirotta, NHMRC Career Development Fellow
Yena (Grace) Kim, Scholarly Selective student
Kristi Milley, Administrative support
Kitty Novy, Administrative support
Centre for Epidemiology & Biostatistics, University of Melbourne;
Royal Melbourne Hospital;
Peter McCallum Cancer Centre;
Cancer Council of Victoria;
Department of Health Victoria
Victorian Comprehensive Cancer Centre
NHMRC Centre for Research Excellence [APP1042021]