In vitro brain tumour model – studying epileptic seizure development and sensitivity to anti-cancer therapy
Malignant brain tumours are notoriously difficult to treat and are often complicated by severe epileptic seizures. Research into therapies has been hampered by a limited range of model systems to explore pathogenesis and treatment of these tumours. We have developed an in vitro model of aggressive brain tumours using a rat brain culture technique that actually develops epeileptic discharges. This uses several well-characterised human tumour cell lines as well as tumour “stem-cells” available in our laboratories. These are seeded into a section of brain maintained in tissue culture.
The project has two aims – to examine the effects of conventional and novel treatments on the tumours as well as the development of epileptic seizure activity in the system. Seizure development will be assayed by electrophysiological recordings.
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Royal Melbourne Hospital
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