Current Projects
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Research Capabilities of Linked Datasets (RCOLD)
This project will supplement the first large-scale, comprehensive data linkage that links primary care and hospital data for cancer patients under the Victorian Comprehensive Cancer Centre’s Data-Driven Research Program. PAT012/PAT019/PAT1033
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Cancer Health Services Utilisation Across the Continuum of Care
This program of work will allow for in-depth analyses utilising state-wide hospital data alongside available primary care data to map how patients engage with and move between these services. PAT073/PAT1032
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PELICAN: Primary care and gEnomic data LInkage for CANcer research
The overarching aim of this research is to create a linked dataset containing patient genomic, primary care and cancer registry data to enable development and evaluation of personalised cancer risk prediction tools incorporating genetic information for use in patients presenting with symptoms of possible cancer to primary care. PAT083
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Diagnostic intervals, predictors of diagnostic delays and associated survival outcomes in haematological malignancies
Investigating diagnostic intervals, predictors of diagnostic delays and associated survival outcomes in haematological malignancies. PAT1032_4
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Examining diagnostic pathways for people with early-onset colorectal cancer using linked primary care, cancer registry and health administrative datasets
The incidence of colorectal cancer in people aged younger than 50, early-onset colorectal cancer (eoCRC), is increasing globally. This study will use linked primary care, cancer registry and health administrative data to compare diagnostic pathways for younger and older adults with colorectal cancer. PAT1032_10
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The role of pre-diagnosis and treatment intervals on colorectal cancer outcomes
To assess the relationship between intervals of time before treatment in Victorian colorectal cancer patients on overall survival and stage at diagnosis. PAT1099
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Machine learning methods for cancer risk prediction of upper gastro-intestinal cancers
This project aims to develop machine learning and advanced statistical methods for the prediction of upper gastro-intestinal (GI) cancers in Australian primary care patients. PAT1124
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Examining diagnostic pathways for people with early-onset sarcoma and early-onset colorectal cancer
This project will allow for in-depth analyses utilising state-wide hospital data alongside available primary care data to map how younger cancer patients are diagnosed with sarcoma and colorectal cancers and compare this to research using similar data-sets from the Netherlands. PAT1125
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Survivorship care and outcomes for women post treatment for endometrial cancer
To describe healthcare utilisation patterns and care-seeking behaviours among women with high-intermediate and high-risk endometrial cancer across three timepoints. PAT1138
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Examining the role of comorbid conditions in the cancer care pathway
This project aims to increase our knowledge on how chronic conditions are managed alongside cancer in general practice and whether there are any deviations from optimal care in the cancer diagnostic and survivorship period for people with chronic illnesses. PAT1040
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Routes to Diagnosis of Cancer
This project will use Patron data to understand the role of primary care in cancer diagnosis, access, treatment and follow-up/survivorship. PAT1044
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Trialing the implementation of a quality assurance framework in the Patron program
Quality assurance of data contributed to the Patron primary care data repository is a core deliverable of the Patron program of research. As part of this quality assurance, we are characterising the data in-terms of its completeness, error rates, temporal characteristics, original intent, meaning and its ability to be utilized to answer specific research questions. PAT004
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Future Health Today
The overarching aim of this research is to evaluate the implementation and effectiveness of Future Health Today (FHT) to support the delivery of guideline concordant care in 90 general practices using a mixed methods approach guided by the Knowledge to Action cycle. PAT051
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Torch Recruit testing and feasibility analyses
Torch Recruit Pty Ltd is a company that aids the determination of the feasibility of clinical trials in general practice and to facilitate clinical trial recruitment in general practice. This project will use an annual datacut of Patron data to undertake technical (data) feasibility assessments for clinical trials, and to undertake development and validation testing of Torch Recruit algorithms. PAT084
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The National Antimicrobial Prescribing Survey
The aim of this project is to utilise the Patron dataset to apply data science methodologies to enable the automation aspects of antimicrobial guideline compliance and appropriateness antibiotic assessment. PAT1029_2
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GooD4Mum
The GooD4Mum study is a general practice – real world (pragmatic) trial to address system, practice and individual level barriers to implementation of guideline recommendations to increase type 2 diabetes mellitus (T2DM) screening and lifestyle ‘Prevention Program’ uptake after Gestational Diabetes Mellitus (GDM). PAT1009
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Exploring opportunities for reducing diagnostic delay for children with type 1 diabetes in Australian general practice
This two part project will utilise the Patron dataset to further our understanding of the main contributors to diagnostic delay for paediatric type 1 diabetes following a visit to the GP. PAT1019
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Data Quality in General Practice EMRs - Is it sufficient for building Clinical Decision Support Tool for Type 2 Diabetes Risk?
This project will aim to assess if the data quality within EMR data fields regarding type 2 diabetes risk factors is sufficient for building a risk prediction algorithm to provided clinical decision support within general practice software. PAT1024
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Understanding and exploring adolescent health presentations in the Victorian primary care setting
This project uses Patron data to describe adolescent and young people's 2019 presentations to general practice in Victoria Australia. PAT011
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Optimising Diagnosis and Management of Hearing Loss by General Practitioners – the HEarIng loss Data Infrastructure (HEIDI) Study
Advancing the knowledge base on the management of hearing loss in the GP setting. This project contributes towards shaping evidence-based clinical guidelines for best practice management of adults with hearing loss, a data-driven approach through the integration of multiple-sources of data and big-data oriented visual and predictive analytics. PAT046
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Global impact of the COVID-19 pandemic on primary care: An international comparative study by the INTRePID consortium
This research will use general practice EMR data stored in repositories based in nine countries to describe general practice consultation types prior to and during the COVID-19 pandemic in 12 primary care systems. PAT043
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Evaluation of natural language processing of general practice free text health records
This project aims to examine EMR data including progress notes to investigate the types of clinical data that are collected to help guide clinical coding requirements for automating outcome measurement and ascertainment in future general practice-based research studies. PAT058/1029
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‘RAd Trial: Investigating NLP mechanisms to identify risk behaviours and health conditions present in GP notes for the purposes of undertaking the RAd RCT
The aim of this project is to undertake an analysis of free text GP notes to establish how we can identify risk taking behaviour and other related health conditions and information to support the RAd RCT trial. PAT1029_0
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The Simply B Trial
This pilot study determines the feasibility, acceptability and effectiveness of Simply B, a novel GP hepatitis B e-support package designed to increase hepatitis B management by GPs in primary care clinics. PAT086
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Exploring Telehealth as a Tool to Reduce Burden on Rural and Regional Victorian GPs
This research project aims to assess the use of telehealth by general practitioners and understand the complexity of patients they treat. Epidemiology and data linkage methodologies will be employed utilising data from PATRON. PAT1043
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Blood pressure changes over 3 years in a resistant severe hypertensive crisis population
This project aims to identify patients who have severe resistant hypertension and look at their natural progression over a historical three year time period in order to compare them to similar patients who have severe resistant hypertension who were treated with renal denervation. PAT1058
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Blood pressure changes over 3 years in a resistant severe hypertensive crisis population - sub project
The aim of this subproject is to detail the prevalence and determinants of MAFLD and CLD risk factors and liver fibrosis in a primary care population. To determine the accuracy of FIB-4 performed in primary care in the prediction of liver-related events (decompensation and HCC). And to identify at-risk populations in primary care in whom a FIB-4 based screening approach should be used to predict risk of future liver-related events. PAT1067
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Investigating individualised health trajectories in underrepresented populations with GP records
This study will evaluate the utility of mining general practice (GP) records to improve ME/CFS diagnosis, characterisation and management in primary care. PAT1092
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DEAR-COPD Programme : Diagnosis through Early Assessment during Respiratory events
The DEAR-COPD initiative is a program of work that investigates whether respiratory exacerbations in primary care can serve as diagnostic windows for COPD. PAT1082
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PRE-DEAR: A Pilot Retrospective Evaluation of Diagnostic Timing Around Exacerbations in Asthma and COPD
This project aims to determine what proportion of asthma and COPD diagnoses by a general practitioner (GP) occur around the time of an exacerbation, and how many exacerbation events typically precede diagnosis. PAT1098
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Activating pharmacists to reduce medication related problems: The ACTMed stepped wedge randomised controlled trial
ACTMed is a new service designed to proactively find and address medicine problems before they cause harm. Participating pharmacists will use a specially designed software program (Actionable medication safety dashboard) that works within health IT systems to detect medicines problems. PAT052
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The National Antimicrobial Prescribing Survey
The aim of this project is to utilise the Patron dataset to apply data science methodologies to enable the automation aspects of antimicrobial guideline compliance and appropriateness antibiotic assessment. PAT061
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Building and evaluating machine learning models to classify appropriateness of antimicrobial prescriptions
This project aims to utilise the Patron dataset to explore the feasibility of a passive GP NAPS and develop algorithms using machine learning to automate compliance and appropriateness antibiotic assessment. PAT063
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Antibiotic prescribing excellence in primary care - APEX PC
The aim of this project is to implement an antimicrobial stewardship (AMS) program into general practice to provide timely audit and reporting to GPs using automation, along with education webinars and information resources to support best practice antibiotic prescribing and quality improvement. PAT1028
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Analysis of antibiotic prescribing by general practitioners for dental conditions in Australia
This project will assess the types of dental conditions that present in general practice as well as the types and regimen of antibiotics prescribed for these conditions. Using Patron data, we will analyse the types of dental conditions that present; the antibiotics that are prescribed; and the guideline compliance of these antibiotics. We will also assess the proportion of dental conditions that did not result in an antibiotic prescription. PAT1060
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The use of Electronic Health Record Monitoring for the Pharmacovigilance of Medicinal Cannabis.
The aim of this project is to quantify the reporting of medicinal cannabis prescribing and identify associations between patient characteristics, conditions, adverse events, and service utilisation as found in Patron general practice EMR records from 1 January 2015 to 31 December 2023. PAT033/1109
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Markers in Neuropsychiatric Disorders (MiND) – utility of neurofilament light chain as a screening test in general practice
Exploring the utility of neurofilament light chain as a marker of diagnosis, staging/severity, prognosis and health economics utility, in the early assessment and care for patients with undiagnosed neurocognitive, neurological and psychiatric symptoms, where there is a differential diagnosis of a possible neurodegenerative disorder. PAT016
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Assessing health care utilisation among older people with cognitive impairment
This project will investigate primary care use among older people with cognitive impairment including those living with dementia. We will explore patterns of primary care use, and the quality of care provided in the first three years following diagnosis and during the last 12 months of life; and further explore care among socially disadvantaged groups. PAT1055
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The effect of the herpes zoster vaccine on vascular inflammation-related health outcomes
This project aims to determine the effect of herpes zoster vaccination on the incidence of shingles and postherpetic neuralgia, and does the herpes zoster vaccine have effects on health beyond the prevention of shingles episodes, such as on cardiovascular disease events and cognition. PAT093
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Syphilis testing by serology and TP PCR in Victorian general practice - Novel strategies for improving syphilis testing and control
This project aims to evaluate the impact of multiplex PCR testing for T. pallidum (TP) and HSV on syphilis detection and diagnosis in Victorian general practice and to evaluate syphilis testing in general practice against known risk factors for infection. PAT077
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