Graduate Research Degree Awarded - Blake Robert Cordingley Smith

Congratulations to Blake Robert Cordingley Smith - Graduate Research Degree Awarded 10 August 2021.

Degree: PhD
Supervisors: Ken Pang, Johannes Kern, George Varigos
Advisory Committee: Shireen Lamande, Sarah Stephenson

Thesis Title: Models and treatments of Dominant Dystrophic Epidermolysis Bullosa

Thesis Summary: This thesis describes the creation and characterisation of several novel mouse models of the rare genetic skin disorder, Dominant Dystrophic Epidermolysis Bullosa (DDEB). To begin, the thesis details the generation and evaluation of five novel mouse lines, two of which directly model the most common human DDEB mutations found in collagen VII. Finally, the thesis describes the use of these mice as a model to better understand and treat EB-related pain.

Date awarded: 10 August 2021