The GP-OSMOTIC trial: Continuous Glucose Monitoring in Type 2 Diabetes

Project Details

Rationale and objectives for research

GP OSMOTIC is a newly awarded NHMRC funded study (2016-18) led by the Department of General Practice at the University of Melbourne and a strong international, multi-institution and multidisciplinary team. The trial tests a novel digital wearable device  for monitoring  glyceamic levels in people with type 2 diabetes (T2D).

The primary research question of the study is– Is targeted, intermittent retrospective Continuous Glucose Monitoring (r-CGM) a cost-effective way of helping patients with T2D achieve glycaemic targets in primary care? The study also offers a unique opportunity to gather robust data on the prevalence of hypoglycaemia amongst a GP T2D population.

Unstructured-Self Monitoring of Blood Glucose (US-SMBG) is ineffective whereas structured-SMBG can improve glycaemic levels. Retrospective continuous glucose monitoring (rCGM), as a more acceptable and user-friendly form of S-SMBG, is particularly useful in T2D (with day-to-day similarity in glycaemic profile), where intermittent, judicious glycaemic profiling can help patient and GP discuss treatment options in a highly personalised way. Our own pilot work suggests r-CGM is acceptable and feasible in primary care and may be effective.

Study Design

The OSMOTIC study is an individually randomised controlled trial.


The study is set in General Practices in Victoria, Australia


Approximately 60 general practices and 240 people with T2D will participate in the study

When final results will be reported/timeline/are preliminary results available?

The OSMOTIC study will be complete in mid-2018, shortly after which final outcome results will be reported.

Website link


Associate Professor John Furler
Louise Ginnivan, Credentialled Diabetes Educator
Katie De La Rue, Research Officer and Study Co-ordinator


Chief Investigators OSMOTIC

Associate Professor John Furler
Professor James Best, Dean Lee Kong Chian Medical School, Nanyang Technological University, Singapore Associate Professor David O'Neal, Department of Medicine, St Vincent's Hospital
Professor Jane Speight, School of Psychology, Deakin University;  Director, Australian Centre for Behavioural Research in Diabetes
Irene Blackberry Director, John Richards Initiative | Australian Institute for Primary Care & Ageing, College of Science, Health and Engineering, La Trobe University,Honorary Senior Research Fellow, Department of General Practice
Professor Kamlesh Khunti, Primary Care Diabetes & Vascular Medicine, University of Leicester, Honorary Professorial Fellow
Dr Kim Dalziel

Associate Investigators

Professor Danny Liew
Mark Kennedy, General Practitioner and Clinical Associate Professor
Professor Philip Clarke
Ralph Audehm, General Practitioner and Clinical Associate Professor
Professor Alicia Jenkins


NHMRC Project Grant Funding: $864,980
Faculty of Medicine, Dentistry and Health Sciences, Research Fellowship Scheme: General Practice Optimising Structured MOnitoring To Improve Clinical outcomes in Type 2 Diabetes. The GP-OSMOTIC study

Research Group

Diabetes and Cardio-Metabolic Conditions

Faculty Research Themes

Infection and Immunology

School Research Themes


Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

General Practice