The GP-OSMOTIC trial: Continuous Glucose Monitoring in Type 2 Diabetes

Project Details

Rationale and objectives for research

GP OSMOTIC is a newly awarded NHMRC funded study (2016-18) led by the Department of General Practice at the University of Melbourne and a strong international, multi-institution and multidisciplinary team. The trial tests a novel digital wearable device  for monitoring  glyceamic levels in people with type 2 diabetes (T2D).

The primary research question of the study is– Is targeted, intermittent retrospective Continuous Glucose Monitoring (r-CGM) a cost-effective way of helping patients with T2D achieve glycaemic targets in primary care? The study also offers a unique opportunity to gather robust data on the prevalence of hypoglycaemia amongst a GP T2D population.

Unstructured-Self Monitoring of Blood Glucose (US-SMBG) is ineffective whereas structured-SMBG can improve glycaemic levels. Retrospective continuous glucose monitoring (rCGM), as a more acceptable and user-friendly form of S-SMBG, is particularly useful in T2D (with day-to-day similarity in glycaemic profile), where intermittent, judicious glycaemic profiling can help patient and GP discuss treatment options in a highly personalised way. Our own pilot work suggests r-CGM is acceptable and feasible in primary care and may be effective.

Study Design

The OSMOTIC study is an individually randomised controlled trial.


The study is set in General Practices in Victoria, Australia


Approximately 60 general practices and 240 people with T2D will participate in the study

When final results will be reported/timeline/are preliminary results available?

The OSMOTIC study will be complete in mid-2018, shortly after which final outcome results will be reported.

Website link


  • Associate Professor John Furler
  • Dr Jo-Anne Manski-Nankervis
  • Louise Ginnivan, Credentialled Diabetes Educator
  • Katie De La Rue, Research Officer and Study Co-ordinator
  • Mrs Kylie Crisp, Project Coordinator/Research Support Officer
  • Rebecca Hannam, Research Assistant
  • Emily Knights Research Assistant
  • Lee-Anne Manski, Administrative Support
  • Jason Chiang, PhD candidate


Chief Investigators OSMOTIC

  • Associate Professor John Furler
  • Professor James Best, Dean Lee Kong Chian Medical School, Nanyang Technological University, Singapore
  • Associate Professor David O'Neal, Department of Medicine, St Vincent's Hospital
  • Professor Jane Speight, School of Psychology, Deakin University;  Director, Australian Centre for Behavioural Research in Diabetes
  • Irene Blackberry Director, John Richards Initiative | Australian Institute for Primary Care & Ageing, College of Science, Health and Engineering, La Trobe University,Honorary Senior Research Fellow, Department of General Practice
  • Professor Kamlesh Khunti, Primary Care Diabetes & Vascular Medicine, University of Leicester, Honorary Professorial Fellow
  • Dr Kim Dalziel
  • Dr Elizabeth Holmes-Truscott, Research Fellow, Australian Centre for Behavioural Research in Diabetes

Associate Investigators


NHMRC Project Grant Funding
Faculty of Medicine, Dentistry and Health Sciences, Research Fellowship Scheme: General Practice Optimising Structured MOnitoring To Improve Clinical outcomes in Type 2 Diabetes. The GP-OSMOTIC study
Abbott: Supply of continuous glucose monitoring devices

Research Group

Diabetes and Cardio-Metabolic Conditions

Faculty Research Themes

Infection and Immunology

School Research Themes


Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

General Practice and Primary Care

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