Breast Cancer

Research Overview

Dr Skandarajah’s main research interests are clinical trials into tailored treatments in early breast cancer, prevention and screening of patients at high risk of developing breast and endocrine malignancies and outcomes in emergency general surgery.

Key research areas:

  • Value-based outcomes research in surgery
  • Patient reported outcomes after breast cancer surgery and risk-reducing surgery
  • De-escalation of therapies after cancer diagnosis

We established the surgeon-led Emergency General Surgical service at The Royal Melbourne Hospital in 2011 and set up a clinical database, which was autopopulated from the admission episode system (iPM) from our institution. The database has been built to be flexible to capture morbidity and mortality in real-time and to validate admission diagnoses, operations and complications. Projects include outcomes after Emergency General Surgery comparing a new model of care to an older established care of surgical patients was the largest study at the time evaluating over 7000 patients and showed a 47% reduction in mortality and 56% decrease in mortality. Other completed studies evaluated the impact on the management of acute biliary disease, liver trauma, trauma in pregnancy.

Administrative data is routinely collected on all patients who are admitted to a hospital in Australia. Patient demographics, diagnosis, length of stay, procedures and complications are all captured in this fashion. Built for the purpose of billing, it also offers a unique opportunity to be used for the purpose of clinical outcomes research. The strength of administrative data as a research tool is its extremely large numbers, low cost and completeness. We have used various platforms for data linkage and have enabled comparative projects such as international variation in management and morbidity and mortality after acute diverticultis and colorectal cancer resection and using administrative data to act as surrogates for cancer databases.

De-escalation of therapies of low value after breast cancer is a focus of our work and we focus our research on clinical trials to evaluate this. The PROSPECT (Post-operative Omission of Radiotherapy after Early Breast Cancer) has completed accrual.

Staff

Associate Professor Ian Hayes

Associate Professor Thomson

Research Opportunities

This research project is available to PhD students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

View Dr Anita Skandarajah's latest PubMed publications here

Research Projects

This Research Group doesn't currently have any projects



Faculty Research Themes

Cancer

School Research Themes

Cancer in Medicine, Women's Health



Key Contact

For further information about this research, please contact Head of Group Professor Bruce Mann

Department / Centre

Surgery

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