Melbourne Brain Centre Imaging Unit
STAFF
Professor Leigh Johnston is the Director of the Melbourne Brain Centre Imaging Unit and a member of the Department of Biomedical Engineering within the School of Chemical and Biomedical Engineering. Her primary research focus is medical imaging, in particular Magnetic Resonance Imaging. She holds an honorary appointment at the Florey Institute of Neuroscience and Mental Health. She coordinates the Melbourne Brain Centre Imaging Unit, with research programs utilising the Siemens 7T and Siemens PET/CT clinical systems on the Parkville campus. Her expertise in MRI spans from acquisition sequences to image analysis and applications. Prior to her appointment at The University of Melbourne, Leigh was a postdoctoral researcher at the Howard Florey Institute (Melbourne), York University (Canada), and the Université catholique de Louvain (Belgium).
Carly Beveridge is our Research Nurse working in the MBCIU to support participants through their imaging appointments to ensure they have best possible care and experience, always working to put study participants at ease.
Carly has come into the MBCIU with several years of nursing experience in Emergency Departments where she has developed and refined her nursing skills. As a nurse she is applying her knowledge and experience to make a great difference to our operations, participants and researchers alike.
Carly has always been fascinated about how the brain and body work and is enjoying learning and working on the wide of research topics and projects supported at the MBCIU.
Dr Yasmin Blunck is a Doreen Thomas Postdoctoral Fellow in the Department of Biomedical Engineering within the School of Chemical and Biomedical Engineering. She is affiliated with the Melbourne Brain Centre Imaging Unit where she develops new methods on the 7T research MRI. Her current research focus is on Sodium Imaging with a particular interest in image acquisition, i.e. sequence development, and reconstruction techniques.
Prior to her PhD at the University of Melbourne where she graduated in 2018, she received a Bachelor of Science in Biomedical Engineering from the University of Applied Sciences Stralsund, Germany, and a Master of Science in Biomedical Computing from the Technical University of Munich, Germany.
During her academic degrees, she completed internships at the Montreal Neurological Institute, Fraunhofer Mevis, Siemens Healthineers and IBM research where she worked on various projects in biomedical imaging.
Dr. Katie (Catherine) Davey is a Lecturer in the Biomedical Engineering Department at the University of Melbourne. Katie's primary research areas are in functional MRI - the acquisition and analysis of a series of low resolution magnetic resonance images to understand brain function - and spike timing dependent synaptic plasticity (STDP) - the process by which connected neurons adapt connection strengths during learning. Katie's research uses advanced signal processing methods, in conjunction with simulation and modelling techniques, to mathematically and programmatically model cortical processes and gain insight into how we perceive and process sensory information.
Katie has additional collaborations, such as with Imperial College of London to investigate the encoding and storage of location information by place cells using calcium imaging, and with Florey Institute of Neurosciences in modelling the neural pathways for bowel disease.
Katie completed her doctoral research in functional MRI connectivity, which is a field of research that analyses a series of low resolution MRI images to identify how brain regions cooperate to achieve sensory and perception tasks. After completing her Ph.D. Katie worked at the Defence Science Technology Organisation, modelling pilot cognition and aircraft control. She then worked in finance, modelling and predicting the movement of stock prices on the S&P500.
Dr Georgia Giannakis is the MBCIU Platform Manager and brings experience from a range of medtech, diagnostic and medical research roles. Georgia has an extensive background in business development and research facility operations, including client, finance and contract management. In her most recent role, Georgia was the Clinical Development Manager at Bionic Vision Technologies Pty Ltd, the company that was established from the Bionic Vision Australia consortium where she was involved in the coordination of project activities leading up to the clinical trial of the Australian bionic eye. Her role encompassed project management, risk and document management associated with the clinical trial, (ethics submissions, risk management, device specification documentation, regulatory approvals, associated SOPs and GCP trial documentation).
Within the MBCIU Georgia is available to assist with all service enquiries, contract and business operational matters.
Rebecca Glarin is the Supervisor Radiographer for the 7T MRI Imaging service. She brings with her a wealth of knowledge regarding the safe use of MRI for research and clinical services with over 20 years of experience in the field.
Her position is responsible for assisting in protocol development and liaising with facility users to provide optimal imaging protocols specifically developed to address the group’s research aims. The position acquires scans involving human participants on the 7T MRI system and is responsible for the delivery and testing of MRI sequences for both human and phantom-based research. In addition, it is also responsible for data quality control, data curation and management of the MRI bookings system and DaRIS data distribution system, and responsible for the development of safe operating procedures at the facility.
Rebecca is a PhD candidate in the Baker Department on Cardiometabolic Health at the University of Melbourne. Her current work is the investigation of sympathetic drive by combining microneurography with ultra-high field functional MRI. The primary aim is to identify subcortical nuclei and the autonomic circuitry responsible for blood pressure control and thermoregulation.
Simon is the Siemens Healthineers on-site scientist dedicated to foster R&D collaborations around 7T MRI with the MBCIU academic team. While supporting the research activity on technical topics, he is driving the research projects on parallel transmission (pTx) pulse design and sequence development to improve image quality and unlock the full potential of 7T MR systems.
As for his academic background, he holds an Engineering degree from Ecole des Mines (France), a Research Master degree in MRI of the spinal cord from Polytechnique Montreal (Canada), a Ph.D. in 7T MRI from Aix-Marseille University (France) and he completed a Postdoc at University Hospital Erlangen (Germany) in pTx pulse design at 7T and in 0.55T MRI of the lung. He was elected as Junior Fellow of the International Society for Magnetic Resonance in Medicine (ISMRM) in 2022, before joining Siemens Healthineers in June 2022.
Associate Professor Brad Moffat
Associate Professor Brad Moffat is a medical imaging physicist and chemist with 19 years’ research experience in the Biomedical Imaging fields of MRI and Molecular Imaging. Since graduating from his PhD in 2001 he has made an excellent contribution to this field. He is currently a fellow for The University of Melbourne node of the National Imaging Facility. He has specific expertise in quantitative Ultra High Field (7 Tesla) MR imaging of human subjects and Molecular Imaging biomarker research, development and clinical translation (Royal Melbourne Hospital 2007-14). He has published significant journal articles on fMRI, diffusion MRI, functional diffusion mapping, MR perfusion, MRS, voxel based morphometry, PET and nano-theranostics. NIF fellow. Performs operations management for both 7T MRI and PET/CT. His specific research interests are in the development of UHF MRI technology and molecular imaging analytics. More specifically he conducts research on UHF-MRI pulse sequences, MRI contrast agents, endogenous quantitative UHF MRI, MRI/PET/CT reconstruction techniques, image analytics in clinical trials and molecular imaging informatics.
Tudor is an MRI Radiographer at the MBCIU. He has 10 years of clinical experience in MRI and Interventional Radiology and was previously the Supervising Radiographer in a Cardiac Catheterisation Laboratory. Tudor holds a Bachelor of Applied Science (Medical Radiations – Medical Imaging) and is a Magnetic Resonance Safety Officer (MRSO), (MRSC™).
Dr Warda Syeda is the Imaging Analysis Fellow at MBCIU, with research interests focused on developing processing and modelling techniques for ultra-high field MRI, such as quantitative susceptibility mapping (QSM) and sodium MRI. Prior to commencing this role, Dr Syeda led pre-clinical neuroimaging at the Melbourne Neuropsychiatry Centre, University of Melbourne. Dr Syeda’s interdisciplinary research aims to facilitate the clinical integration of advanced research in neuropsychiatric disorders, such as autism, schizophrenia and schizotypy disorders in children. She has a background in Electrical and Biomedical Engineering and provides expert contributions in methods development for advanced multivariate image processing and inference.
Mr Rob Williams is the National Imaging Facility Fellow (PET) Chief Research Technologist (PET) at the Melbourne Brain Centre Imaging Unit. Rob has had a diverse range of international experience in the world of nuclear medicine. Rob is also a presenter and the producer of the Nuclear Medicine and Molecular Medicine Podcast. The Podcast is the world’s longest running medical podcast, the highest ranked and most listened to podcast in the field of Nuclear Medicine and PET
Rob has worked as principle Molecular Medicine Technologist at the time, the largest hospital in Europe. He has worked as an applications specialist and development advisor to imaging companies and has trained technologists and medical registrars in Europe, Australia and India. And has worked to develop training via the international atomic energy agency, the Indo-European educational forum and the European Association of nuclear medicine, he is the current CPD chair for the Australian society of nuclear medicine. And is a lecturer at RMIT for nuclear medicine undergraduates. He has been instrumental in developing many research projects and is passionate about improving PET and SPECT reconstruction having been involved in its early development. While not “nuc medding” he loves the beach and is an active surf lifesaver and scuba diver.
PhD CANDIDATES
Danis Aslan is a PhD student in the Department of Biomedical Engineering. His research project is focused on the Bloch Equation and Rotating matrix. Danis graduated with a Master of Mathematics at Ege University and a Bachelor’s degree at the same University.
Joseph Bartlett is undertaking a joint PhD between the University of Melbourne and the University of Birmingham, funded by the Melbourne Research Scholarship. His research focus is on machine learning approaches for improved diffusion MRI. He has completed a Masters of Science in Artificial Intelligence and Machine Learning at the University of Birmingham and was awarded the Computer Science School Prize. He completed his Bachelor of Science in Mathematics at the University of Manchester.
Yining Chen is a PhD student in the Department of Radiology under the Faculty of Medicine, Dentistry and Health Sciences. Her research focuses on the investigation of ultra-high-field MRI biomarkers of chronic traumatic brain injuries. Yining has completed a Bachelor of Diagnostic Radiography at the University of Sydney and a Master of Molecular Imaging Technology at the University of Queensland.
Jamie Elliott is a PhD student in the Department of Biomedical Engineering, University of Melbourne. His research focuses on identifying MRI and PET biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Jamie holds a Bachelor of Pharmaceutical Science from Monash University and conducted his Honours research project at the Florey Institute of Neuroscience and Mental Health.
Mara Quach is a PhD student in the Department of Biomedical Engineering, University of Melbourne. Her research is focused on Chemical Exchange Saturation Transfer (CEST) at ultra-high-field. Mara has a Bachelor of Biomedicine and a Master of Engineering from Melbourne University. In Addition to her current post Graduate studies, Mara works for the Alfred Research Alliance as a research assistant on preclinical imaging projects using diffusion-weighted MRI and QSM for application in motor neuron diseases, traumatic brain injury, and other disorders.
Igor Tyshchenko is a PhD student in the Department of Biomedical Engineering. His research project investigates the parallel transmission capabilities in ultra-high field MRI. Prior to his PhD, Igor completed his Master of Engineering (Biomedical) at the University of Melbourne as well as his Bachelor’s degree in Biotechnical Sciences and Technologies at the Ural Federal University, Russia.
MBCIU Alumni
Featured content
Siemens 7 Tesla MRI Scanner
Our Siemens Magnetom 7 Tesla Ultra High Field Magnetic Resonance Imaging scanner is one of only two in Australia. This state of the art scanner provides unprecedented image quality allowing acquisition of non-invasive structural, functional and molecular information at exquisite spatial and temporal resolutions.
The 7T MRI scanner was purchased from Siemens and installed on the ground floor of the Melbourne Brain Centre at Parkville in March 2014. The MBCIU has a Master Research Agreement with Siemens that allows the latest MRI technology to be available on the scanner for research collaborators before they are commercially available.
Research studies on the 7T continue to be primarily neuroimaging focused, however the node has expanded applications with an increase of non-brain studies, given exemplary new functionality with the eye and cervical spine coils, and the flexibility of the knee coil to study wrists and other peripheral limb sections.
The facility maintains world’s best practice for the following applications and expertise:
- Quantitative structural MRI
- Spectroscopy Imaging
- Quantitative Susceptibility Mapping (QSM)
- Sodium MRI
- Neuro-Vascular Imaging (Time of Flight and SWI)
- Functional MRI (fMRI)
- Ultra-high field MRI Safety (Accredited MRI safety officer and expert)
The MBCIU is the University of Melbourne Node of the National Imaging Facility (NIF, https://anif.org.au/). This facility has funded the purchase and operations of the Human 7T MRI and PET/CT scanners via the Australian Government NCRIS program, and Victorian Government matching funds. The purpose was to provide Australian scientists with world-class neuroimaging facilities.
Siemens PET-CT Scanner
The Imaging Unit within the Melbourne Brain Centre at Parkville houses a state-of-the-art PET-CT scanner, which has been funded under the umbrella of a successful VSA bid submitted by the Victorian Biomedical Imaging Consortium (VBIC). Radiopharmaceuticals can be scanned in order to study tissue function and metabolism and novel biomarkers are being used to study brain disorders such as Alzheimer's disease. The system can provide time-of-flight measurements and has an extended field of view PET with 128-slice CT.
The Human PET/CT has continued to be well utilised in a broad range of research studies and clinical trials. Optimised reconstruction is developing as a focus for the UOM PET/CT team, using dedicated access to the Siemens e7 toolbox, and in collaboration with CSIRO for standardised tracer uptake computation. A primary objective of this work is to derive metrics by which to evaluate scanner harmonisation in multicentre studies.
MELBOURNE BRAIN CENTRE IMAGING UNIT
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Melbourne Brain Centre Imaging Unit
Ground Floor - Kenneth Myer Building
30 Royal Parade, The University of Melbourne.
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You can help us by volunteering for clinical and research studies. The MBCIU is involved in numerous trials involving many debilitating diseases. Contact us to learn more about how you can help shape the future of research at the University of Melbourne.